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Microtechnologies and instrumentation

Our goal is not only to develop nano, micro, and millifluidic devices but also to integrate in situ analysis, if possible, or to make compatible the devices with analytical characterization. We describe below examples of on chip light scattering, X-Ray scattering, infrared thermography, etc. and also some our fabrication procedures.

Membres :

Automation DLS : Dynamic Light Scattering for Colloidal Size Measurements Microfabrication Robotics, High Throughput Formulation and Phase Diagram Investigation SAXS : Small Angle X-Ray Scattering Experiments Thermal Methods for Characterizing Chemical Reactions

DLS : Dynamic Light Scattering for Colloidal Size Measurements

DLS has rarely been combined with microfluidics, compared to other existing techniques such as X-ray scattering, spectroscopy... Actually, online DLS measurements are difficult to perform due to the high shear rates involved in miniaturized pressure-driven flows.

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SAXS : Small Angle X-Ray Scattering Experiments

Microfluidics is a well-established tool for studying chemical reactions at small time scales (? 100 ms) and with minute amounts of sample (? µL). In particular, the combination of microfluidics and Small Angle X-ray Scattering (SAXS) probing colloidal sizes and structures is promising to study kinetics of nucleation-growth-aggregation mechanisms. [1] [2]

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Thermal Methods for Characterizing Chemical Reactions

The knowledge of chemical reactions kinetics and thermodynamics is required for chemical process development and safety. Heat transfer and chemical kinetics occur during chemical reactions. One way to control and measure those phenomena is calorimetric measurements we develop in our lab at the microscale level with non invasive techniques.

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As microfluidics needs to control precisely fluid flows in complex geometries, precise machining and processes are required. Our activity focalised on chemistry issues implies the use of chemical actives, solvents and also to work in severe conditions in terms of pressure and temperature. Cost, versatility, ease of use, number of devices, speed and industrial relevancy are constraints lead our approach and let us choose among different technologies. Here are two samples of what the LOF can (...)

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Robotics, High Throughput Formulation and Phase Diagram Investigation

Robotics and High Throughput Screening (HTS) tools and combinatorial methodologies can be used to accelerate the preparation of formulations and to screen a large set of parameters (type of ingredients, ratios, temperature, pH, ...) by miniaturization and parallelization. Several challenges have to be addressed in the field of formulation : highly viscous materials need to be handled with a good precision and efficiently mixed at small scale, characterization devices and algorithms need to (...)

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High throughput screening usually aims at finding the best set of an often complex parameter space related to sample preparation (e.g. formulation or synthesis) and/or process parameters which optimizes one or several figures of merit (e.g. sample or process properties). In general it consists of 4 steps : Design of experiment (DOE), preparation of samples, determination of sample properties and data analysis. The overall screening throughput is finally limited by the component of this (...)

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