Sébastien Lecommandoux, LCPO, Bordeaux
9 janvier 2015
We report an overview on the self-assembly in water of amphiphilic block copolymers into polymersomes, and their applications in loading and controlled release of both hydrophilic and hydrophobic molecules and biomolecules. We pay special attention to polysaccharide and polypeptide-based block copolymer vesicles that we have studied these recent years in our group. These newly developed copolymers that mimic the structure and function of glycoproteins represent an example of the effectiveness of a biomimetic strategy in implementing materials design. In addition, magnetic polymersomes, including iron oxide γ-Fe2O3 nanoparticles are currently investigated, together with their potential applications as contrast agent for imaging and as therapeutic nanoparticles using hyperthermia. Exciting and very promising results about their therapeutic evaluation for tumor targeting and in vivo tumor regression studies will be presented.
Finally our recent advances in using “biomimicry approaches” to design complex, compartmentalized materials will be proposed. We demonstrate the formation of compartmentalized polymersomes with an internal « gelly » cavity using an original and versatile emulsion-centrifugation process. Such a system constitutes a first step towards the challenge of structural cell mimicry with both “organelles” and “cytoplasm mimics”. This study constitutes major progress in the field of structural biomimicry and will certainly enable the rise of new, highly interesting properties in the field of high-added value soft matter, especially in controlled cascade (bio)reactions
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